TOXICITY & SAFETY - DRACONIS PHARMA
30
page-template-default,page,page-id-30,ajax_fade,page_not_loaded,,qode-title-hidden,qode-theme-ver-10.1.1,wpb-js-composer js-comp-ver-5.0.1,vc_responsive,elementor-default

Drug discovery services

Toxicity & Safety

Systemic toxicity Assessment:
Hematology (cell population counts)
Clinical chemistry
Gross pathology
Organs weight
Histopathology
Analysis of serum proteins
Serum gamma-immunoglobulins levels
Immunophenotyping
Serum cytokines quantification

 

In vitro tests for Direct immunotoxicity detection:

Mixed Lymphocyte Reaction (MLR)
T cell proliferation/ differentiation / Phenotyping
Antibody-Dependant Cell Toxicity (ADCC)
Cytotoxic T-lymphocyte assay (CTL)
Human NK Cells
Complement-Dependent Cytotoxicity (CDC)
Dendritic Cell Maduration
Human Whole Blood Cytokine production

 

Immunogenicity/Tolerogenicity assessment:

Delayed-Type Hypersensitivity (DTH)
T-cell Dependent Antibody Response (TDAR)

 

Allergenicity assessment:
Total or specific IgE measurement
Ex-vivo proliferation of isolated spleenocytes
Molecular interaction with skin proteins. Direct Peptide Reactivity Assay (DPRA)
Inflammatory response in keratinocytes. ARE-Nrf2 Luciferase test
Activation of dendritic cells. Expression of CD86/CD54 in THP-1 cells (h-CLAT)

laboratory Mouse

Este sitio web utiliza cookies para que usted tenga la mejor experiencia de usuario. Si continúa navegando está dando su consentimiento para la aceptación de las mencionadas cookies y la aceptación de nuestra política de cookies, pinche el enlace para mayor información.plugin cookies

ACEPTAR
Aviso de cookies