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Drug discovery services

Toxicity & Safety

Systemic toxicity Assessment:
Hematology (cell population counts)
Clinical chemistry
Gross pathology
Organs weight
Analysis of serum proteins
Serum gamma-immunoglobulins levels
Serum cytokines quantification


In vitro tests for Direct immunotoxicity detection:

Mixed Lymphocyte Reaction (MLR)
T cell proliferation/ differentiation / Phenotyping
Antibody-Dependant Cell Toxicity (ADCC)
Cytotoxic T-lymphocyte assay (CTL)
Human NK Cells
Complement-Dependent Cytotoxicity (CDC)
Dendritic Cell Maduration
Human Whole Blood Cytokine production


Immunogenicity/Tolerogenicity assessment:

Delayed-Type Hypersensitivity (DTH)
T-cell Dependent Antibody Response (TDAR)


Allergenicity assessment:
Total or specific IgE measurement
Ex-vivo proliferation of isolated spleenocytes
Molecular interaction with skin proteins. Direct Peptide Reactivity Assay (DPRA)
Inflammatory response in keratinocytes. ARE-Nrf2 Luciferase test
Activation of dendritic cells. Expression of CD86/CD54 in THP-1 cells (h-CLAT)

laboratory Mouse

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