TARGET & CELL-BASED ASSAYS - DRACONIS PHARMA
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Drug discovery services

Target & Cell-based assays

Target-based assays

Draconis provides fully customized assays using isolated pharmacological targets to perform biochemical assays (e.g G-coupled protein receptors, enzymes, interleukin/cytokine receptors, nuclear receptors, DNA,…). The assays are designed to provide insight into the interaction and mode-of-action of drugs designed to inhibit or activate pharmacological targets. Depending on the studied target, Draconis works with different systems such as isolated proteins, cellular membranes ….

 

Cell-based assays

Draconis provides our clients a powerful and versatile tool to study the functional states of various cell types or diseases in the fields of inflammation and immunology. tThe assays we currently have developed are designed to provide insight into the immune response or related processes (see below) and the translation of in-vitro results into a specific pathology or disease.

 

All studies can be adapted to customer requirements. We also have the knowledge and skills to optimize and develop new cell-based assays that are required by our customers.

  • Stimulus-induced activation
  • Proliferation
  • Differentiation and Maturation (Dendritic cells, T cells,…)
  • Gene Expression profiling
  • Cytokine production profiling
  • Phenotyping of immune cells
  • Immuno-oncology assays (e.g co-cultures tumor cells with immune cells)
  • Degranulation
  • Respiratory burst
  • Phagocytosis
  • Whole cell based assays
  • Migration & Chemotaxis
  • Cell death & Apoptosis
  • Antibody production (IgG, IgM, IgE)
  • Antibody-dependent-cell mediated cytotoxicity (ADCC)
  • Complement-dependent cytotoxicity (CDC)
  • Gated Autofluorescence Forward Scatter Assay (GAFS)
  • Cytotoxic T Lymphocyte Killing Assay (CTL)
  • Tolerogenicity assays
  • Mixed-lymphocyte reaction (MLR)

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