One of Draconis Pharma strengths relies on the extensive use of unique specific models of a wide array of human diseases within the inflammatory, autoimmune and allergy areas. These models help select those compounds that have the best chance of clinical and commercial success. All studies can be adapted to customer requirements. We also have the knowledge and skills to optimize and develop new animal models that are required by our customers.
Rheumatoid arthritis
• CIA: Collagen-Induced Arthritis in mice (DBA/1) or rats (Lewis).
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- o B- and T-cell dependent model; Th1/Th17 phenotype; MHCII-linked susceptibility. 8 weeks.
• CAIA: Collagen Antibody-Induced Arthritis in mice (Balb/c).
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- o Macrophages- and polymorphonuclear cells-dependent model; Th1 phenotype. 2 weeks.
• AIA: Adjuvant-Induced Athritis in rats (Lewis).
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- o T-cell (CD4+/CD8+) dependent model; Th1 phenotype. 4 weeks.
Inflammatory Bowel Disease
• DSS-induced colitis in mice (C57Bl/6).
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- o Induced by Dextran sulphate sodium (DSS); Th1/Th2 phenotype. 1-3 weeks.
• TNBS-induced colitis in mice (C57Bl/6) and rats (Wistar).
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- o Induced by Trinitrobenzenesulfonic acid (TNBS); Th1 phenotype. 1 week.
Acute inflammation
• Thioglycollate- or Zymosan- induced peritonitis in Mice (C57Bl/6).
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- o Leukocyte dependent; Th1 phenotype. 1-48 hours.
Allergic/Contact dermatitis
• Hapten-induced Delayed Hypersensitivity in mice (Balb/c).
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- o Induced by Oxazolone (OXA) or 2,4-dinitrofluorobenzene (DNFB); T-cell (CD4+) dependent model; Th1 phenotype.
Atopic dermatitis
• FITC-induced Contact Hypersensitivity in mice (Balb/c).
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- o Induced by Fluorescein isothiocyanate (FITC); T-cell (CD4+/CD8+) dependent model; Th2 phenotype. 1 week.
• OXA-induced Chronic Dermatitis in mice (Balb/c).
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- o Induced by Oxazolone (OXA); T-cell (CD4+/CD8+) dependent; Th1/Th2 phenotypes. 4 weeks.
Psoriasis
• OXA-induced Hypersensitivity in mice (Balb/c).
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- o Induced by Oxazolone (OXA); T-cell (CD4+) dependent model; Th1 phenotype. 8 days.
• TPA-induced Delayed Hypersensitivity in mice (Balb/c, CD1).
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- o Induced by 12-O-tetradecanoylphorbol-13-acetate (TPA); T-cell (CD4+) dependent model; Th17 phenotype. 10 days.
• Imiquimod-induced psoriasis-like skin inflammation in mice (Balb/c).
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- o Induced by Imiquimod. T-cell (CD4+) dependent model; Th17 phenotype. 7-10 days.
In each animal model, specific readouts will be applied. Immunological and pharmacological parameters can also be analyzed depending on the customer requirements.