In-vivo Efficacy

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One of Draconis Pharma strengths relies on the extensive use of unique specific models of a wide array of human diseases within the inflammatory, autoimmune, allergy and pain areas. These models help select those compounds that have the best chance of clinical and commercial success.

Once proof-of-activity has been determined on cell-based assays, the next step is to obtain proof-of-principlr of efficacy in animal models. 

´╗┐Draconis Pharma has expertise in different therapeutic areas such as inflammation, autoimmunity, allergy and pain. Thus, we are currently performing a number of animal models reproducing human pathologies or inflammatory processes.

(for further information or specific requirements, please contact us )

General inflammatory models
  • LPS-induced endotoxic shock (rat or mouse)
  • Zymosan-induced peritonitis (mouse)
  • Air pouch (rat)
  • Carrageenan-induced paw edema (rat)
  • CFA-induced paw edema (rat)
Delayed-type hypersensitivity assays
  • Oxazolone-induced DTH (mouse)
  • FITC-induced DTH (mouse)
  • DNBC-induced DTH (mouse)
  • SRBC-induced DTH (mouse)
Rheumatoid arthritis models
  • Collagen-induced arthritis (CIA) (rat, mouse)
  • Adjuvant-induced arthritis (AIA) (rat)
  • Collagen antibody-induced arthritis (CAIA) (mouse)
  • Monosodium iodoacetate-induced arthritis (MIA) (rat)
Intestinal bowel disease models
  • TNBS-induced bowel inflammation (rat, mouse)
Neuroinflammatory models
  • Experimental Autoimmune Encephalomyelitis (EAE) (mouse)
Respiratory and allergy disease models
  • HDM-induced bronchial hyperresponsiveness (mouse)
  • OVA-induced bronchial hyperresponsiveness (mouse, rat)
Pain models
Nociceptive and inflammatory pain
  • Hot plate analgesia
  • Tail flick analgesia
  • Capsaicin (mouse)
  • Formalin test (rat, mouse)
  • CFA-induced thermal hyperalgesia and/or mechanical allodynia (rat)
  • Carrageenan-induced thermal hyperalgesia and/or mechanical allodynia (rat)
Post-operative pain
  • Incisional pain (Brennan) (rat)
Visceral pain
  • Acetic acid-induced abdominal pain (writhing test) (rat, mouse)
  • Cyclophosphamide-induced cystitis (rat)
 
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